:root{--ink:#18392f;--green:#28684e;--muted:#7b837d;--line:#e2e5de;--bg:#f7f8f3;--white:#fff;--accent:#ce7955;--soft:#edf3e9}*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--ink);font:14px/1.6 -apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}button,input,textarea,select{font:inherit}button,a,input,textarea,select{ -webkit-tap-highlight-color:transparent}button{cursor:pointer}button:disabled{opacity:.5;cursor:wait}button:focus-visible,a:focus-visible{outline:3px solid #b3cdb1;outline-offset:3px}a{color:var(--green)}.sidebar{position:fixed;inset:0 auto 0 0;width:230px;padding:37px 22px;background:#193b30;color:#ebf0e8;display:flex;flex-direction:column}.brand{display:flex;gap:14px;align-items:center;color:inherit;text-decoration:none;font-size:16px;line-height:1.35;letter-spacing:.2px}.brand b{font-weight:400;color:#b8cabc}.brand-icon{font:36px Georgia,serif;border:1px solid #7c9b83;width:54px;height:54px;border-radius:13px;text-align:center;padding-top:5px}.brand-icon span{color:#e4af82}.nav-caption{margin:62px 12px 16px;color:#96b0a0;font-size:10px;letter-spacing:1.8px}.nav{border:0;background:none;color:#b8cabc;text-align:left;padding:13px 14px;border-radius:7px;margin:3px 0;display:flex;gap:12px;align-items:center}.nav.active{background:#315143;color:#fff}.nav span{font-size:20px}.sidebar-bottom{margin-top:auto;font-size:11px;color:#bed0c0;padding:20px 10px 0;border-top:1px solid #3a5748}.sidebar-bottom p{color:#8daa98;font-size:10px;margin:6px 0 18px}.version{font-size:10px;color:#91ac9c}.local-dot{display:inline-block;border-radius:50%;background:#b1cb88;width:6px;height:6px;margin-right:6px}main{margin-left:230px;padding:0 42px;max-width:1760px}header{height:86px;display:flex;justify-content:space-between;align-items:center;border-bottom:1px solid var(--line);font-size:10px;letter-spacing:1.5px;color:var(--muted)}header 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0}.privacy,.help{color:var(--muted);font-size:11px;line-height:1.7}.privacy{font-size:9px;margin:13px 0 0}.empty-state{text-align:center;min-height:360px;display:flex;flex-direction:column;align-items:center;justify-content:center;background:radial-gradient(ellipse at center,#f3f7ee,#fff 70%)}.molecule-watermark{font:100px/1 Georgia,serif;color:#94b59b;margin:0 0 13px}.empty-state h2{font:26px Georgia,serif;margin:14px 0 4px}.empty-state p{font-size:12px;color:var(--muted)}.empty-state .eyebrow{font-size:8px}.feature-row{display:flex;gap:25px;color:var(--accent);font-size:10px;margin-top:18px}.feature-row b{font-weight:400;color:#647265;margin-left:4px}.generation-panel{margin-top:20px}.tag{font-size:8px;letter-spacing:1px;color:#7b8c6c;background:#f1f4e8;padding:4px 7px;border-radius:4px}.generation-controls{display:grid;grid-template-columns:1fr 100px;gap:12px;margin-top:18px}select{display:block;background:#fcfcfa;border:1px solid var(--line);border-radius:5px;padding:8px;color:var(--ink);font-size:11px;width:100%;margin-top:6px}.generation-controls label{font-size:10px;color:var(--muted)}.error{background:#fff0eb;border:1px solid #f0c5b3;color:#9c4931;border-radius:8px;padding:13px;margin-bottom:14px;font-size:12px}.busy{padding:14px;background:#eaf2e7;margin-bottom:14px;border-radius:8px;display:flex;gap:10px;align-items:center;font-size:12px}.spinner{border:2px solid #b1c5aa;border-top-color:var(--green);width:16px;height:16px;border-radius:50%;animation:spin 1s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.result-top{display:flex;justify-content:space-between;align-items:center}.result-top .tag{background:#e9f2e8}.structure-view{width:100%;height:230px}.structure-view svg{width:100%;height:100%}.canonical{word-break:break-all;color:#708371;background:#f4f7ef;border-radius:5px;padding:8px 10px;font-size:10px;margin:10px 0 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p{font-size:13px;color:#69786b;line-height:1.9}.instructions h2{margin:22px 0 12px}.instructions h2:first-child{margin-top:0}pre{background:#f0f4eb;padding:18px;line-height:2;overflow:auto;border-radius:6px}.pipeline{display:flex;gap:12px;align-items:center;flex-wrap:wrap;margin:22px 0}.pipeline span{background:#eef3e8;padding:10px;border-radius:5px;font-size:11px}.pipeline b{font-weight:400;color:var(--accent)}footer{display:flex;justify-content:space-between;gap:20px;color:#90988d;font-size:9px;letter-spacing:.3px;border-top:1px solid var(--line);margin:40px 0 20px;padding-top:16px}.hidden{display:none!important}.editor-tools{display:flex;align-items:center;gap:6px;flex-wrap:wrap;margin-bottom:10px}.editor-tools label{font-size:9px;margin:0}.editor-tools select{display:inline-block;width:auto;padding:4px;font-size:10px;margin:0 0 0 3px}#editor{width:100%;height:auto;background-color:#fafcf7;border:1px solid var(--line);border-radius:7px;touch-action:none}#editor text{font-family:sans-serif;font-size:16px;dominant-baseline:central;text-anchor:middle;pointer-events:none}#editor circle{cursor:pointer}#editor line{pointer-events:none}.file-label{font-size:10px;color:var(--green)}input[type=file]{max-width:100%;font-size:10px;display:block;margin-top:8px}.dropzone{border:1px dashed #b6c8ac;border-radius:8px;padding:24px 12px;text-align:center;cursor:pointer;background:#fafcf6;display:flex;flex-direction:column;align-items:center;gap:8px}.dropzone span{font-size:10px;color:var(--muted)}.dropzone .upload-icon{font-size:28px;color:var(--green)}.dropzone input{width:100%}#image-preview{max-width:100%;max-height:200px;display:block;margin:12px auto}.resolved{margin-top:15px;border:1px solid #c1d4b5;background:#f7faf2;padding:12px;border-radius:8px}.resolved svg{width:100%;height:150px}.resolved .help{font-size:10px}.resolved .secondary{width:100%;margin-top:8px}details summary{font-size:11px;cursor:pointer;color:var(--green)}@media(min-width:1500px){main{padding:0 58px}.workspace-grid{gap:28px}.panel{padding:29px}}@media(max-width:1100px){.sidebar{width:190px;padding:30px 15px}main{margin-left:190px;padding:0 24px}.workspace-grid{grid-template-columns:1fr}.results-column{display:grid;grid-template-columns:1fr}.empty-state{min-height:260px}.candidate-grid{grid-template-columns:1fr 1fr}.status-pills{gap:4px}.pill{font-size:9px;padding:4px 7px}}@media(max-width:650px){.sidebar{position:static;width:auto;padding:16px;flex-direction:row;align-items:center;gap:8px}.brand{font-size:11px;margin-right:auto}.brand-icon{font-size:25px;width:36px;height:36px;border-radius:8px;padding:2px}.nav{font-size:0;padding:6px}.nav span{font-size:20px}.nav-caption,.sidebar-bottom{display:none}main{margin:0;padding:0 16px}header{height:65px;gap:8px;font-size:8px;letter-spacing:.7px;flex-wrap:wrap;justify-content:flex-start;padding:12px 0}.page-heading{padding:28px 0 24px}h1{font-size:31px}.page-heading p{font-size:12px}.panel{padding:19px}.candidate-grid,.model-grid{grid-template-columns:1fr}.metrics{gap:6px}.metric{padding:9px}.metric .value{font-size:20px}.section-heading .subtle{display:none}footer span:last-child{display:none}.feature-row{gap:12px}.tab{padding:10px}.workspace-grid{grid-template-columns:minmax(0,1fr)}}
/* Generation targets */
.global-message{margin-top:20px}.property-option{border:1px solid var(--line);border-radius:8px;padding:14px;margin:12px 0;background:#fcfdf9}.property-check{display:flex;align-items:flex-start;gap:10px;margin:0 0 10px}.property-check input{accent-color:var(--green);margin-top:5px}.property-check b{font-size:12px;font-weight:550}.property-check small{display:block;color:var(--muted);font-size:10px;font-weight:400}.property-option>label:not(.property-check){display:flex;align-items:center;justify-content:space-between;font-size:10px;margin-bottom:0;color:#647365}.property-option input[type=number]{width:85px;border:1px solid #ced9c6;border-radius:5px;padding:6px 8px;color:var(--ink);background:white;font-size:12px}.property-option .help{font-size:9px;margin-bottom:0}.property-option:has(input[type=checkbox]:checked){border-color:#9ab88d;background:#f3f7ed}.match-badge{float:right;font-size:8px;border-radius:4px;padding:2px 5px}.match-badge.met{color:#326544;background:#eaf3e1}.match-badge.unmet{color:#956140;background:#faf0e3}.target-checks{margin:12px 0}.target-check{display:grid;grid-template-columns:1fr auto;gap:2px 5px;padding:7px 0;border-bottom:1px solid var(--line);font-size:10px}.target-check small{grid-column:1/-1;font-size:9px;color:var(--muted)}.target-check.met>span{color:#3c774d}.target-check.unmet>span{color:#ab7042}.target-check b{font-weight:500}.generator-layout{align-items:start}
/* Reviewed molecular design workflow */
#design-plan,#confirm-controls{margin-top:24px}#offline-builder input,.design-advanced input,.clarification input{display:block;width:100%;border:1px solid var(--line);padding:9px 10px;background:#fcfcfa;color:var(--ink);border-radius:6px;font-size:12px;margin:6px 0 13px}#offline-builder label,.design-advanced label{margin-top:12px}.design-advanced{margin:18px 0}.design-advanced summary{font-size:12px}.plan-steps{display:grid;gap:10px;margin:18px 0}.plan-step{border-left:3px solid #9eb88f;background:#f7faf2;padding:10px 14px}.plan-step b{font-size:13px}.plan-step .help{margin:3px 0}.numbered-seed{max-width:650px;margin:auto}.numbered-seed svg{width:100%;height:auto}.clarification{padding:16px;margin:12px 0;background:#fbf6eb;border:1px solid #e6d5ae;border-radius:8px}.design-warning{font-size:11px;color:#976536;background:#fcf4e6;padding:9px;border-radius:6px}#design-plan ul{font-size:12px;padding-left:20px}textarea:disabled{background:#eff1ec;color:#92978d}#confirm-controls .primary{max-width:420px}#design-plan p{font-size:13px}#design-plan .help{font-size:11px}#review-plan{margin-top:18px}
/* PCR sequence workspace */
.pcr-fields{display:grid;grid-template-columns:repeat(auto-fit,minmax(135px,1fr));gap:12px;margin:18px 0}.pcr-fields input{display:block;width:100%;padding:9px;border:1px solid var(--line);border-radius:6px;color:var(--ink);background:white}.pcr-fields label{font-size:11px}#pcr-mode{width:100%;padding:10px;margin:8px 0;border:1px solid var(--line);border-radius:6px;background:white;color:var(--ink)}#pcr-design{margin-top:20px}#pcr-results{margin-top:30px}.pcr-candidate{margin:18px 0}.pcr-table-wrap{overflow-x:auto}.pcr-table{width:100%;border-collapse:collapse;font-size:12px;text-align:left}.pcr-table th,.pcr-table td{padding:12px 10px;border-bottom:1px solid var(--line)}.pcr-table .mono{white-space:nowrap}.pcr-candidate details{margin-top:16px}.pcr-candidate details p{font-size:12px}.pcr-sequence{overflow-wrap:anywhere}#pcr-results pre{white-space:pre-wrap;overflow-wrap:anywhere}#pcr-results>.section-heading{flex-wrap:wrap;gap:12px}
#boltz-msa{display:block;width:100%;margin:10px 0;padding:10px;background:white;border:1px solid var(--line);color:var(--ink);border-radius:6px}#boltz-samples{display:block;width:100px;padding:8px;border:1px solid var(--line);border-radius:6px}#boltz-plan,#boltz-job{margin-top:24px}#boltz-job a{display:inline-block;font-size:11px;text-decoration:none;overflow-wrap:anywhere}#boltz-job .result-actions{flex-wrap:wrap}#boltz-job .detail-grid{margin-bottom:20px}

@media(max-width:650px){.sidebar{flex-wrap:wrap;gap:6px}.sidebar .brand{flex-basis:100%;margin-bottom:6px}.sidebar .nav{flex:1;justify-content:center;gap:0;margin:0;padding:6px 2px}}
.structure-3d{margin:24px 0}.structure-3d select,#boltz-history{display:block;width:100%;padding:8px;margin:8px 0;border:1px solid var(--line);background:white;color:var(--ink);border-radius:6px}.structure-tools{display:flex;flex-wrap:wrap;align-items:center;gap:12px;margin:14px 0}.structure-tools label{display:flex;gap:6px;align-items:center;margin:0;font-size:12px}.structure-canvas{height:440px;width:100%;position:relative;overflow:hidden;border-radius:10px;background:#f4f7f8}.structure-canvas canvas{touch-action:none}.structure-3d .structure-status{min-height:24px}@media(max-width:650px){.structure-canvas{height:340px}}
#input-3d{margin-top:24px}.input-3d-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:24px}.input-3d-grid .structure-canvas{height:360px}.input-3d-grid input[type=file]{max-width:100%;margin-bottom:12px}.input-3d-grid p{min-height:48px}@media(max-width:800px){.input-3d-grid{grid-template-columns:1fr}}
.structure-tools .fit-distance{width:auto;margin:0;padding:5px}.fit-residues{max-height:280px;overflow:auto}.fit-confidence{margin:14px 0}